Variants in autophagy genes affect susceptibility to both Crohn's disease and Helicobacter pylori infection.
نویسندگان
چکیده
منابع مشابه
Vacuolating cytotoxin and variants in Atg16L1 that disrupt autophagy promote Helicobacter pylori infection in humans.
BACKGROUND & AIMS The Helicobacter pylori toxin vacuolating cytotoxin (VacA) promotes gastric colonization, and its presence (VacA(+)) is associated with more-severe disease. The exact mechanisms by which VacA contributes to infection are unclear. We previously found that limited exposure to VacA induces autophagy of gastric cells, which eliminates the toxin; we investigated whether autophagy s...
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Helicobacter pylori (H. pylori) is a gram-negative microaerophilic bacterium that has been introduced as a cause of mucosal inflammation and gastric cancer. The most important pathogenic factors are VacA and CagA, which are associated with increased disease severity in clinical strains. Autophagy is a protected lysosomal degradation pathway degrading cytoplasmic content and is important in host...
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Background: Laboratory studies have shown that gastric epithelial infection cells with Helicobacter pylori (H. pylori) can increase autophagy. Disruption in this process can cause various diseases, including cancer. Objective: This study aims to compare the serum level of Autophag -Related Gene 5 (ATG5) in individuals with and without H. pylori infection. Methods: This case-control pilot stud...
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Abstract Background and objectives: most common causes of morbidity and mortality in industrial and developing countries. Recent studies have suggested that A coronary heart disease is one of the Helicobacter pylori heart disease therefore, this study was carried out in Gorgan, Iran, to show the relationship between coronary disease and Helicobacter pylori infection. ca...
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ورودعنوان ژورنال:
- Gastroenterology
دوره 142 5 شماره
صفحات -
تاریخ انتشار 2012